The Health Benefits of CBD Oil
What is CBD Oil?
CBD oil contains CBD or Cannabidiol, which is one of over a hundred compounds found in the cannabis plant that belongs to a class of substances called cannabinoids. Whereas CBD is the major non-psychotropic component, THC or tetrahydrocannabinol is the ingredient that produces mind-altering effects in users. Simply put, the health benefits of CBD oil cannot be overstated, and the evidence is not merely anecdotal but supported by research.
Importantly, CBD oil is perfectly legal in South Africa as a result of its ultra-low THC content.
How does CBD Oil Work?
CBD Oil works because it contains the exogenous cannabinoid CBD, and the human body contains an Endocannabinoid system, which according to the Wikipedia Online Encyclopedia “is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems.” Cannabinoids manifest their effects by interacting with the body’s endocannabinoid system, that responds to cannabinoid ‘agonists’, or chemical messengers. The endocannabinoid system is responsible for the psychological and physiological effects of cannabinoids, of which there are two types: endocannabinoids, which originate inside the body, 2-AG and anandamide are the two most significant endocannabinoids and exogenous cannabinoids which arise outside of the body, such as the THC and CBD in cannabis.
What are the Health Benefits of CBD Oil?
The health benefits of CBD oil are numerous. It exhibits potent antioxidant, analgesic, anti-cancer, anti-inflammatory and antipsychotic effects. It alleviates the cognitive decline associated with ageing, and it also reduces the risk of diabetes.
Studies show that CBD has a significant impact on various neurological and physiological disorders such as:
- Amyotrophic Lateral Sclerosis (ALS)
- Attention Deficit Hyperactivity Disorder (ADHD)
- Attention-Deficit Disorder (ADD)
- Chronic pain
- Gastrointestinal Disorders
- Multiple Sclerosis (MS)
- Muscular Dystrophy
- Obsessive-Compulsive Disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Phantom Limb
- Spinal injury
Chart of the Medicinal Benefits of Cannabinoids
Hover over the chart to zoom in.
The Therapeutic Effects of CBD Oil
The Biology and Potential Therapeutic Effects of Cannabidiol: View Research Paper
A number of studies over the last two decades or more have reported that CBD has anti-seizure activity, reducing the severity of seizures in animal models. In addition, there have been a number of case studies and anecdotal reports suggesting that CBD may be effective in treating children with drug-resistant epilepsy.
CBD Oil as a Treatment for ADD/ADHD
ADD/ADHD symptoms are typified by low dopamine and high cortisol levels and can be reduced by CBD, which increases dopamine and lowers cortisol levels in the body. While some studies have investigated cannabis as a treatment for symptoms of ADD/ADHD, few have considered the efficacy of CBD in particular. However, there is a great deal of anecdotal evidence supporting the effectiveness of CBD as a treatment for symptoms of ADD/ADHD.
Cannabinoids in attention-deficit/hyperactivity disorder: View Research Paper
Adults with ADHD may represent a subgroup of individuals who experience a reduction of symptoms and no cognitive impairments following cannabinoid use. While not definitive, this study provides preliminary evidence supporting the self-medication theory of cannabis use in ADHD and the need for further studies of the endocannabinoid system in ADHD.
CBD Oil for Pain Management
Cannabinoids in the management of difficult to treat pain: View Research Paper
Cannabidiol, a non-euphoriant phytocannabinoid common in certain strains, shares neuroprotective effects with THC, inhibits glutamate neurotoxicity, and displays antioxidant activity greater than ascorbic acid (vitamin C) or tocopherol (vitamin E).
CBD additionally affects THC function by inhibiting first pass hepatic metabolism to the possibly more psychoactive 11-hydroxy-THC, prolonging its half-life, and reducing associated intoxication, panic, anxiety and tachycardia.
Additionally, CBD is able to inhibit tumor necrosis factor-alpha (TNF-α) in its own right in a rodent model of rheumatoid arthritis.
CBD Oil as an Anti-Inflammatory
Cannabinoids as a novel anti-inflammatory: View Research Paper
Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2). The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
CBD Oil as a Cancer Treatment
Cannabidiol as a potential anticancer drug: View Research Paper
Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
Cannabidiol inhibits angiogenesis by multiple mechanisms: View Research Paper
This study reveals that CBD inhibits angiogenesis by multiple mechanisms. Its dual effect on both tumour and endothelial cells supports the hypothesis that CBD has potential as an effective agent in cancer therapy.
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1: View Research Paper
Altogether, these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers.
CBD Oil as a Treatment for Alzheimer’s
In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease: View Research Paper
The studies provide “proof of principle” that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies.
CBD Oil as a Treatment for Anxiety and Insomnia
The effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: View Research Paper
The main finding from this case study is that CBD oil can be an effective compound to reduce anxiety and insomnia secondary to PTSD. A review of the literature suggests some benefits from the use of CBD because of its anxiolytic and sleep-inducing effects.
CBD Oil as a Treatment for Epilepsy
CBD-enriched medical cannabis for intractable pediatric epilepsy: View Research Paper
CBD treatment yielded a significant positive effect on seizure load. Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported <25% reduction. Five (7%) patients reported aggravation of seizures which led to CBD withdrawal. In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep.
Hypnotic and antiepileptic effects of cannabidiol: View Research Paper
Seven out of the eight epileptics receiving cannabidiol had improvement of their disease state, whereas only one placebo patient improved.
CBD Oil as a Treatment for Arthritis
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis: View Research Paper
The data presented here indicate that local administration of CBD blocked OA pain. Prophylactic CBD treatment prevented the later development of pain and nerve damage in these OA joints. These findings suggest that CBD may be a safe, useful therapeutic for treating OA joint neuropathic pain.
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: View Research Paper
Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.
CBD Oil as a Treatment for Multiple Sclerosis (MS)
Cannabidiol to Improve Mobility in People with Multiple Sclerosis View Research Article
There is evidence that CBD has a number of beneficial pharmacological effects (4, 5). It is anti-inflammatory, antioxidative, antiemetic, antipsychotic, and neuroprotective. The review of 132 original studies by Bergamaschi et al. (6) describes the safety profile of CBD by highlighting that catalepsy is not induced and physiological parameters (heart rate, blood pressure, and body temperature) are not altered. Moreover, psychomotor and psychological functions are not negatively affected.
Currently, many PwMS utilize cannabis to manage a variety of symptoms. Kindred et al.) showed in a web-based survey, which was hosted by the National Multiple Sclerosis Society that 66% of PwMS currently use cannabis for symptom treatment.
Cannabidiol Reduces Spasticity, Pain, Inflammation, Fatigue, and Depression in PwMS.
How Much CBD Oil Should I Take?
Ideally, your dosage should be prescribed by qualified and experienced healthcare professional. Various brands of CBD oils have products offering different strengths. Also, different conditions require different dosages to be effective, and some people may need more than others to have the desired effect. Typically, one should start with the recommended dose for a week and build up weekly in small increments until no further benefit is felt. Then, gradually reduce the dosage incrementally until you find an ideal dosage for the desired effect.
What is the Recommended Dose of CBD Oil?
While there is no RDA or officially recommended dose for CBD, there are various clinical studies, research papers and resources from which such information can be drawn:
- Preventative: Up to 10mg/day
- Anxiety: 15 – 25mg/day (Source: Reddit Dosage question about help with anxiety)
- Cancer: 500mg-1000+mg/day or 10mg/kg/day (Source: Cannabidiol as potential anticancer drug)
- Chronic Pain: 2.5 – 20mg/day (Source: Cannabinoids as novel anti-inflammatory drugs)
- Epilepsy: 200 – 300mg/day or 20mg/kg (Source: Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome)
- Glaucoma: 15 – 40mg/day (Source: Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity)
- Sleep Disorders: 50 – 150mg/day (Source: Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report)
- Schizophrenia: 400 – 1250mg/day (Source: A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol as a Treatment for Acutely Ill Schizophrenic Patients)
Where Can I Buy CBD Oil?
Buy CBD Oil Online at Organica
You can purchase CBD products from our online store, and we will courier your package to your door or a nearby collection point anywhere in South Africa. For international customers, select the ‘Quote for Worldwide Shipping’ option at the checkout.