The Health Benefits of CBD
The health benefits of CBD are numerous. It exhibits potent antioxidant, analgesic, anti-cancer, anti-inflammatory and antipsychotic effects. It alleviates the cognitive decline associated with ageing, and it also reduces the risk of diabetes.
Studies show that CBD benefits various neurological and physiological disorders such as:
- Amyotrophic Lateral Sclerosis (ALS)
- Attention Deficit Hyperactivity Disorder (ADHD)
- Attention-Deficit Disorder (ADD)
- Chronic pain
- Gastrointestinal Disorders
- Multiple Sclerosis (MS)
- Muscular Dystrophy
- Obsessive-Compulsive Disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Phantom Limb
- Spinal injury
Chart of the Medicinal Benefits of Cannabinoids
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The Therapeutic Effects of CBD
The Biology and Potential Therapeutic Effects of Cannabidiol: View Research Paper
A number of studies over the last two decades or more have reported that CBD has anti-seizure activity, reducing the severity of seizures in animal models. In addition, there have been a number of case studies and anecdotal reports suggesting that CBD may be effective in treating children with drug-resistant epilepsy.
CBD for ADD/ADHD
ADD/ADHD symptoms are typified by low dopamine and high cortisol levels and can be reduced by CBD, which increases dopamine and lowers cortisol levels in the body. While some studies have investigated cannabis as a treatment for symptoms of ADD/ADHD, few have considered the efficacy of CBD in particular. However, there is a great deal of anecdotal evidence supporting the effectiveness of CBD as a treatment for symptoms of ADD/ADHD.
Cannabinoids in attention-deficit/hyperactivity disorder: View Research Paper
Adults with ADHD may represent a subgroup of individuals who experience a reduction of symptoms and no cognitive impairments following cannabinoid use. While not definitive, this study provides preliminary evidence supporting the self-medication theory of cannabis use in ADHD and the need for further studies of the endocannabinoid system in ADHD.
CBD for Autism
Cannabidiol as a suggested candidate for treatment of autism spectrum disorder: View Research Paper
In this review we summarize the available pre-clinical and clinical data regarding the safety and effectiveness of medical cannabis, including CBD, in young ASD patients. Cannabidiol seems to be a candidate for the treatment of ASD.
Cannabidiol Based Medical Cannabis in Children with Autism: View Research Paper
Results: Following the cannabis treatment, behavioral outbreaks were much improved or very much improved (on the CGIC scale) in 61% of patients. The anxiety and communication problems were much or very much improved in 39% and 47% respectively. Disruptive behaviors, were improved by 29% from 4.74±1.82 as recorded at baseline on the HSQ-ASD to 3.36±1.56 following the treatment. Parents reported less stress as reflected in the APSI scores, changing by 33% from 2.04±0.77 to 1.37±0.59. The effect on all outcome measures was more apparent in boys with non-syndromic ASD. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%).
Conclusions: This preliminary study support the feasibility of CBD based medical cannabis as a promising treatment option for refractory behavioral problems in children with ASD. Based on these promising results, we have launched a large, double blind, placebo controlled cross-over trial with 120 participants.
Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities: View Research Paper
Results: 53 children at a median age of 11 (4-22) year received cannabidiol for a median duration of 66 days (30-588). Self-injury and rage attacks (n = 34) improved in 67.6% and worsened in 8.8%. Hyperactivity symptoms (n = 38) improved in 68.4%, did not change in 28.9% and worsened in 2.6%. Sleep problems (n = 21) improved in 71.4% and worsened in 4.7%. Anxiety (n = 17) improved in 47.1% and worsened in 23.5%. Adverse effects, mostly somnolence and change in appetite were mild.
Conclusion: Parents’ reports suggest that cannabidiol may improve ASD comorbidity symptoms; however, the long-term effects should be evaluated in large scale studies.
Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems: View Research Paper
This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%).
Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients.
CBD for Pain Management
Cannabinoids in the management of difficult to treat pain: View Research Paper
Cannabidiol, a non-euphoriant phytocannabinoid common in certain strains, shares neuroprotective effects with THC, inhibits glutamate neurotoxicity, and displays antioxidant activity greater than ascorbic acid (vitamin C) or tocopherol (vitamin E).
CBD additionally affects THC function by inhibiting first pass hepatic metabolism to the possibly more psychoactive 11-hydroxy-THC, prolonging its half-life, and reducing associated intoxication, panic, anxiety and tachycardia.
Additionally, CBD is able to inhibit tumor necrosis factor-alpha (TNF-α) in its own right in a rodent model of rheumatoid arthritis.
CBD as an Anti-Inflammatory
Cannabinoids as a novel anti-inflammatory: View Research Paper
Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2). The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
CBD for Cancer
Cannabidiol as a potential anticancer drug: View Research Paper
Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.
Cannabidiol inhibits angiogenesis by multiple mechanisms: View Research Paper
This study reveals that CBD inhibits angiogenesis by multiple mechanisms. Its dual effect on both tumour and endothelial cells supports the hypothesis that CBD has potential as an effective agent in cancer therapy.
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1: View Research Paper
Altogether, these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers.
CBD for Alzheimer’s
In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease: View Research Paper
The studies provide “proof of principle” that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies.
CBD for Anxiety and Insomnia
The effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: View Research Paper
The main finding from this case study is that CBD can be an effective compound to reduce anxiety and insomnia secondary to PTSD. A review of the literature suggests some benefits from the use of CBD because of its anxiolytic and sleep-inducing effects.
CBD for Epilepsy
CBD-enriched medical cannabis for intractable pediatric epilepsy: View Research Paper
CBD treatment yielded a significant positive effect on seizure load. Most of the children (66/74, 89%) reported reduction in seizure frequency: 13 (18%) reported 75-100% reduction, 25 (34%) reported 50-75% reduction, 9 (12%) reported 25-50% reduction, and 19 (26%) reported <25% reduction. Five (7%) patients reported aggravation of seizures which led to CBD withdrawal. In addition, we observed improvement in behavior and alertness, language, communication, motor skills and sleep.
Hypnotic and antiepileptic effects of cannabidiol: View Research Paper
Seven out of the eight epileptics receiving cannabidiol had improvement of their disease state, whereas only one placebo patient improved.
CBD for Arthritis
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis: View Research Paper
The data presented here indicate that local administration of CBD blocked OA pain. Prophylactic CBD treatment prevented the later development of pain and nerve damage in these OA joints. These findings suggest that CBD may be a safe, useful therapeutic for treating OA joint neuropathic pain.
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: View Research Paper
Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.
CBD for Multiple Sclerosis (MS)
Cannabidiol to Improve Mobility in People with Multiple Sclerosis View Research Article
There is evidence that CBD has a number of beneficial pharmacological effects (4, 5). It is anti-inflammatory, antioxidative, antiemetic, antipsychotic, and neuroprotective. The review of 132 original studies by Bergamaschi et al. (6) describes the safety profile of CBD by highlighting that catalepsy is not induced and physiological parameters (heart rate, blood pressure, and body temperature) are not altered. Moreover, psychomotor and psychological functions are not negatively affected.
Currently, many PwMS utilize cannabis to manage a variety of symptoms. Kindred et al.) showed in a web-based survey, which was hosted by the National Multiple Sclerosis Society that 66% of PwMS currently use cannabis for symptom treatment.
Cannabidiol Reduces Spasticity, Pain, Inflammation, Fatigue, and Depression in PwMS.
Where Can I Buy CBD?
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Because the topic of CBD is so vast, this article is one of a number of sub-articles that combine that form the mega-article CBD: The Essential Guide. We have done this so that you can more easily process the overview information and delve into the more detailed articles at will.