What is Coenzyme Q10?
Coenzyme Q10, often abbreviated as CoQ10, is an antioxidant that is produced naturally by your body. In its most common forms, it is known as ubiquinone or ubiquinol for the fact that it is ubiquitous in plants, animals, people and most bacteria. Ubiquinone, sometimes called Conventional CoQ10, is produced by the body and is present in the food we eat, however, the body must first convert it into Ubiquinol prior to being used to generate cellular energy. Ubiquinol is a potent antioxidant that protects your cells from damage by free radicals.
How Does CoQ10 Work?
CoQ10 is a fat-soluble substance that is present in almost every cell of your body and participates in cellular respiration, the metabolic process that takes place at a cellular level to convert biochemical energy from nutrients into adenosine triphosphate (ATP), which is the main energy source within cells for metabolic functions. CoQ10 is found in the largest concentrations in organs with the highest rates of metabolism such as the heart, kidneys, liver and pancreas. CoQ10 is essential for the health of all human organs and tissues, however, levels rapidly decline with age and where diseases increase the action of reactive oxygen species, otherwise known as free radicals. Antioxidants such as CoQ10 neutralize free radicals and may even reverse some of the damage they cause.
Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. View Research Paper
In this paper we show that ubiquinol-10, the reduced form of ubiquinone-10, also efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as alpha-tocopherol, which is considered the best lipid-soluble antioxidant in humans.
Which is Better: Ubiquinone or Ubiquinol?
Increased bioavailability of ubiquinol compared to that of ubiquinone… View Research Paper
These data suggest that the enhanced bioaccessibility and bioavailability of ubiquinol compared to ubiquinone results from reduced coenzyme being more efficiently incorporated into mixed micelles during digestion and its greater uptake and basolateral secretion in a glutathione-dependent mechanism.
Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. View Research Paper
The bioavailability of the reduced form of coenzyme Q10 (ubiquinol) was compared to oxidized coenzyme Q10 (ubiquinone) with identical soft gel capsule excipients by measuring steady state plasma coenzyme Q10 (CoQ10 ) levels in 12 healthy volunteers.
Plasma ubiquinol/total CoQ10 ratio increased from baseline during ubiquinol supplementation (P < 0.005) and remained unchanged after ubiquinone supplementation. No side effects were noted in this study.
How is CoQ10 Made?
In the body: Ubiquinone is produced in the liver and then converted to ubiquinol through a process called reduction-oxidation, otherwise known as the “redox cycle”.
In the Lab: Q&A Consumerlab.com
As explained in the “Synthetic vs. Natural” section of the CoQ10 and Ubiquinol Supplements Review, naturally formed CoQ10 is 100% in the “trans” isomer form. Synthetically formed material is also predominantly in the “trans” form with a small amount in the “cis” form. Since the fermentation process using bacteria or yeast is much cheaper than chemical synthesis and provides 100% natural (trans) CoQ10, most, but not all, CoQ10 found in the marketplace today is made by a fermentation process.
What Do People Use CoQ10 For?
Research shows that CoQ10 supplements can lower blood pressure and prevent or treat the adverse effects of taking statin cholesterol drugs. Preliminary studies have indicated that CoQ10 may retard but not reverse the progression of Alzheimer’s disease. CoQ10 is generally accepted as a beneficial treatment following heart failure and lessen the risk of future cardiac problems.
Coenzyme Q10: The essential nutrient: View Research Paper
CoQ10 improves energy, augments the immune system, and acts as an antioxidant. The potential use of coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat some of the following conditions: cardiovascular diseases, high blood pressure, cancer, periodontal diseases, mitochondrial disorders, radiation injury, obesity, diabetes, Parkinson’s disease, acquired immune deficiency syndrome (AIDS), gastric ulcers, allergy, migraine headaches, kidney failure, muscular dystrophy, and aging. CoQ10 plays a significant role in boosting the immune system and physical performance, as tissues and cells involved with immune function are highly energy-dependent and therefore require an adequate supply of CoQ10 for optimal function.
The Health Benefits of CoQ10
Treatment for Diabetes
Novel CoQ10 antidiabetic mechanisms underlie its positive effect: View Research Paper
These results provided a new insight into the possible mechanisms by which CoQ10 improves insulin sensitivity and adjusts type 2 diabetic disorder. These mechanisms involve modulation of insulin and adiponectin receptors, as well as TK, PI3K, glucose transporters, besides improving lipid profile, redox system, sRAGE, and adipocytokines. The study also points to the potential positive effect of CoQ10 as an adds- on to conventional antidiabetic therapies.
May Help Treat Heart Failure
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: View Research Paper
Long-term CoQ10 treatment of patients with chronic HF is safe, improves symptoms, and reduces major adverse cardiovascular events. (Coenzyme Q10 as adjunctive treatment of chronic heart failure: a randomised, double-blind, multicentre trial with focus on SYMptoms, BIomarker status [Brain-Natriuretic Peptide (BNP)], and long-term Outcome [hospitalisations/mortality].
Could Improve Male Fertility
Antioxidant supplements and semen parameters: An evidence-based review: View Research Paper
In most of the studies, antioxidant supplementation improved the number, motility, morphology and sometimes DNA integrity of sperm. The present study showed that antioxidant supplements, especially a combination of antioxidants such as vitamin C, vitamin E, and CoQ10 intake can effectively improve semen parameters in infertile men.
May Treat and Prevent Migraines & Headaches
Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: View Research Paper
A significant reduction was also evident in the severity of headaches (mean decrease: 2.3 vs. 0.6 among CoQ10 and control groups, respectively, p < 0.001). For ≥50 % reduction in the frequency of attacks per month, the number needed to treat was calculated as 1.6. No side effects for CoQ10 were observed. This study suggests that CoQ10 might reduce the frequency of headaches, and may also make them shorter in duration, and less severe, with a favorable safety profile.
How Long Does CoQ10 Take to Work?
If the body’s CoQ10 levels are low, it may take a few weeks for you to notice the full benefits and effects of taking the supplement. However, as levels normalise in the blood plasma, many people should feel an increase in energy within the first week. People over 40 may notice more significant effects, as the body produces less CoQ10.
How Much CoQ10 Should I Take?
There is no officially recognised recommended dose for CoQ10, but many supplement manufacturers recommend a daily dosage of 100-200g split into several doses per day. Follow the instructions on the bottle or consult your doctor or healthcare specialist.
Is CoQ10 Safe?
While CoQ10 is considered safe with few side effects, it is always best to consult your medical practitioner before taking any new supplement.
Where Can I Buy CoQ10?
Buy CoQ10 Online at Organica
You can purchase CoQ10 products from our online store, and we will courier your package to your door or a nearby collection point anywhere in South Africa. For international customers, select the ‘Quote for Worldwide Shipping’ option at the checkout. Take a look at our most popular CoQ10 products below.