cbd oil

How Does CBD Oil Work?

How Does CBD Oil Work?

The Endocannabinoid System

CBD Oil works because it contains the exogenous cannabinoid CBD, and the human body contains an Endocannabinoid system, which according to the Wikipedia Online Encyclopedia “is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems.” Cannabinoids manifest their effects by interacting with the body’s endocannabinoid system, that responds to cannabinoid ‘agonists’, or chemical messengers. The endocannabinoid system is responsible for the psychological and physiological effects of cannabinoids, of which there are two types: endocannabinoids, which originate inside the body, 2-AG and anandamide are the two most significant endocannabinoids and exogenous cannabinoids which arise outside of the body, such as the THC and CBD in cannabis.

CBD and the Immune System

The immune system is comprised of structures and processes within the body that protect against diseases and destroy foreign and infectious microbes. In some instances, the immune system mistakenly attacks healthy tissue, resulting in a condition known as autoimmunity. Cannabidiol (CBD) has been shown by researchers to be an immune system suppressor: one of the reasons why it’s useful in the treatment of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and Crohn’s disease, and why it has improved the quality of life of those suffering from such diseases.

The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT) View Research Paper

Taken together, these data suggest that CBD suppresses T cell function and that CB1 and/or CB2 play a critical role in the magnitude of the in vitro anti-sRBC IgM AFC response.

CBD possesses low affinity for both CB1 and CB2 cannabinoid receptors and therefore, does not produce the “high” associated with marijuana use. Despite this, CBD does exhibit immunosuppressive properties.

CBD and the Sleep Cycle

According to research, CBD improves insomnia and increases the amount of sleep because it reduces anxiety and chronic pain, as opposed to making one sleepy. Interestingly, CBD has also been shown to induce alertness when awake, and it has also been shown to improve REM Sleep Disorder.

How Long Does it Take for CBD to Take Effect?

The time it takes for the effects of CBD to manifest when taken orally depends a great deal on how long ago your last meal was, and how much you ate. Typically, it’s best to take CBD on an empty stomach for the effects to be felt more immediately, as the more substantial and more recently a meal was eaten, the more delayed the effects.

What are the Side Effects of CBD?

Most importantly, CBD will not cause you to get “high” or experience a sensation of intoxication as it has a minimal level of THC, making it non-psychoactive. It will not adversely affect your sensory perception, reflexes, reaction time or your behaviour in general.

Is it Safe to Take CBD?

CBD is safe and non-toxic even at high dosages. According to CannLabs, a testing lab for cannabis products, there is no established lethal dosage of CBD, and interestingly, there have been no reported cases of CBD overdosage.

Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent: View Research Paper

Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters.

An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies: View Research Paper

In general, the often described favorable safety profile of CBD in humans was confirmed and extended by the reviewed research. The majority of studies were performed for treatment of epilepsy and psychotic disorders. Here, the most commonly reported side effects were tiredness, diarrhea, and changes of appetite/weight. In comparison with other drugs, used for the treatment of these medical conditions, CBD has a better side effect profile.

CBD Oil Usage

CBD has a vast range of healing properties. Studies show that it has significant effects on various neurological and physiological disorders. Such disorders include anxiety, ADHD and ADD, Alzheimer’s, arthritis, bipolar, cancer, chronic pain, depression, diabetes, epilepsy, fibromyalgia and hypertension. These in addition to inflammation, insomnia, migraines and headaches, multiple sclerosis, nausea, OCD. Furthermore, many use CBD to treat osteoporosis, Parkinson’s, PTSD, schizophrenia, seizures, spasticity, spinal injury and even stress.

Where Can I Buy CBD Oil?

Buy CBD Oil Online at Organica

You can purchase CBD products from our online store, and we will courier your package to your door or a nearby collection point anywhere in South Africa.

Take a look at our most popular CBD products below.

View our complete range of various CBD product types:

CBD Oil Products
Liposomal CBD Products
Topical CBD Products
CBD Vape Juice Products


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CBD Oil: The Essential Guide

Because the topic of CBD is so vast, this article is one of a number of sub-articles that combine that form the mega-article CBD Oil: The Essential Guide. We have done this so that you can more easily process the overview information and delve into the more detailed articles at will.